Neuronal non-CG methylation is an essential target for MeCP2 function

DNA methylation is implicated in neuronal biology via the protein MeCP2, the mutation of which causes Rett syndrome. MeCP2 recruits the NCOR1/2 co-repressor complexes to methylated cytosine in the CG dinucleotide, but also to sites of non-CG methylation, which are abundant in neurons. To test the bi...

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Udgivet i:Mol Cell
Main Authors: Tillotson, Rebekah, Cholewa-Waclaw, Justyna, Chhatbar, Kashyap, Connelly, John C., Kirschner, Sophie A., Webb, Shaun, Koerner, Martha V., Selfridge, Jim, Kelly, David A., De Sousa, Dina, Brown, Kyla, Lyst, Matthew J., Kriaucionis, Skirmantas, Bird, Adrian
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980222/
https://ncbi.nlm.nih.gov/pubmed/33561390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.011
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