PRMT6 Methylation of RCC1 Regulates Mitosis, Tumorigenicity, and Radiation Response of Glioblastoma Stem Cells

Aberrant cell proliferation is a hallmark of cancer including glioblastoma (GBM). Here we report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells (GSCs), a subpopulation in GBM critical fo...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Huang, Tianzhi, Yang, Yongyong, Song, Xiao, Wan, Xuechao, Wu, Bingli, Sastry, Namratha, Horbinski, Craig M., Zeng, Chang, Tiek, Deanna, Goenka, Anshika, Liu, Fabao, Brennan, Cameron W., Kessler, John A., Stupp, Roger, Nakano, Ichiro, Sulman, Erik P., Nishikawa, Ryo, James, Charles David, Zhang, Wei, Xu, Wei, Hu, Bo, Cheng, Shi-Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979509/
https://ncbi.nlm.nih.gov/pubmed/33539787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.015
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