CSIG-35. MST4 PHOSPHORYLATION OF ATG4B REGULATES AUTOPHAGIC ACTIVITY, TUMORIGENICITY, AND RADIORESISTANCE IN GLIOBLASTOMA

Autophagy is a conserved catabolic process that maintains homeostasis by regulating the energy balance of the cell. Cancer cells use autophagy to remove damaged organelles and aggregated proteins, and to recycle nutrients in high demand to support tumor growth. Radiation therapy (RT) and temozolomid...

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Published in:Neuro Oncol
Main Authors: Huang, Tianzhi, Kwon Kim, Chung, Alvarez, Angel, Pangeni, Rajendra, Wan, Xuechao, Xiao, Song, Shi, Taiping, Yang, Yongyong, Sastry, Namratha, Horbinski, Craig, Lu, Songjian, Stupp, Roger, Kessler, John, Nishikawa, Ryo, Nakano, Ichiro, Sulman, Erik, Lu, Xinghua, James, C David, Yin, Xiao-Ming, Hu, Bo, Cheng, Shi-Yuan
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216764/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.201
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