Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma

Glioma stem cells (GSCs), a subpopulation of tumor cells, contribute to tumor heterogeneity and therapy resistance. Gene expression profiling classified glioblastoma (GBM) and GSCs into four transcriptomically-defined subtypes. Here, we determined the DNA methylation signatures in transcriptomically...

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Bibliografiske detaljer
Udgivet i:Epigenetics
Main Authors: Pangeni, Rajendra P., Zhang, Zhou, Alvarez, Angel A., Wan, Xuechao, Sastry, Namratha, Lu, Songjian, Shi, Taiping, Huang, Tianzhi, Lei, Charles X., James, C. David, Kessler, John A., Brennan, Cameron W., Nakano, Ichiro, Lu, Xinghua, Hu, Bo, Zhang, Wei, Cheng, Shi-Yuan
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140806/
https://ncbi.nlm.nih.gov/pubmed/29927689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2018.1469892
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