Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma

Glioma stem cells (GSCs), a subpopulation of tumor cells, contribute to tumor heterogeneity and therapy resistance. Gene expression profiling classified glioblastoma (GBM) and GSCs into four transcriptomically-defined subtypes. Here, we determined the DNA methylation signatures in transcriptomically...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Epigenetics
Prif Awduron: Pangeni, Rajendra P., Zhang, Zhou, Alvarez, Angel A., Wan, Xuechao, Sastry, Namratha, Lu, Songjian, Shi, Taiping, Huang, Tianzhi, Lei, Charles X., James, C. David, Kessler, John A., Brennan, Cameron W., Nakano, Ichiro, Lu, Xinghua, Hu, Bo, Zhang, Wei, Cheng, Shi-Yuan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2018
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140806/
https://ncbi.nlm.nih.gov/pubmed/29927689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2018.1469892
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