PRMT6 Methylation of RCC1 Regulates Mitosis, Tumorigenicity, and Radiation Response of Glioblastoma Stem Cells

Aberrant cell proliferation is a hallmark of cancer including glioblastoma (GBM). Here we report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells (GSCs), a subpopulation in GBM critical fo...

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發表在:Mol Cell
Main Authors: Huang, Tianzhi, Yang, Yongyong, Song, Xiao, Wan, Xuechao, Wu, Bingli, Sastry, Namratha, Horbinski, Craig M., Zeng, Chang, Tiek, Deanna, Goenka, Anshika, Liu, Fabao, Brennan, Cameron W., Kessler, John A., Stupp, Roger, Nakano, Ichiro, Sulman, Erik P., Nishikawa, Ryo, James, Charles David, Zhang, Wei, Xu, Wei, Hu, Bo, Cheng, Shi-Yuan
格式: Artigo
語言:Inglês
出版: 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979509/
https://ncbi.nlm.nih.gov/pubmed/33539787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.015
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