PRMT6 Methylation of RCC1 Regulates Mitosis, Tumorigenicity, and Radiation Response of Glioblastoma Stem Cells

Aberrant cell proliferation is a hallmark of cancer including glioblastoma (GBM). Here we report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells (GSCs), a subpopulation in GBM critical fo...

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Publicado no:Mol Cell
Main Authors: Huang, Tianzhi, Yang, Yongyong, Song, Xiao, Wan, Xuechao, Wu, Bingli, Sastry, Namratha, Horbinski, Craig M., Zeng, Chang, Tiek, Deanna, Goenka, Anshika, Liu, Fabao, Brennan, Cameron W., Kessler, John A., Stupp, Roger, Nakano, Ichiro, Sulman, Erik P., Nishikawa, Ryo, James, Charles David, Zhang, Wei, Xu, Wei, Hu, Bo, Cheng, Shi-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979509/
https://ncbi.nlm.nih.gov/pubmed/33539787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.015
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