Persistent repression of tau in the brain using engineered zinc finger protein transcription factors

Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we introduce a novel translational approach to lower expression of the tau gene MAPT at the transcriptional level using gene-silencing zinc finger protein transcription factors (ZFP-...

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Bibliografiska uppgifter
I publikationen:Sci Adv
Huvudupphovsmän: Wegmann, Susanne, DeVos, Sarah L., Zeitler, Bryan, Marlen, Kimberly, Bennett, Rachel E., Perez-Rando, Marta, MacKenzie, Danny, Yu, Qi, Commins, Caitlin, Bannon, Riley N., Corjuc, Bianca T., Chase, Alison, Diez, Lisa, Nguyen, Hoang-Oanh B., Hinkley, Sarah, Zhang, Lei, Goodwin, Alicia, Ledeboer, Annemarie, Lam, Stephen, Ankoudinova, Irina, Tran, Hung, Scarlott, Nicholas, Amora, Rainier, Surosky, Richard, Miller, Jeffrey C., Robbins, Ashley B., Rebar, Edward J., Urnov, Fyodor D., Holmes, Michael C., Pooler, Amy M., Riley, Brigit, Zhang, H. Steve, Hyman, Bradley T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for the Advancement of Science 2021
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978433/
https://ncbi.nlm.nih.gov/pubmed/33741591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe1611
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