Persistent repression of tau in the brain using engineered zinc finger protein transcription factors

Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we introduce a novel translational approach to lower expression of the tau gene MAPT at the transcriptional level using gene-silencing zinc finger protein transcription factors (ZFP-...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Wegmann, Susanne, DeVos, Sarah L., Zeitler, Bryan, Marlen, Kimberly, Bennett, Rachel E., Perez-Rando, Marta, MacKenzie, Danny, Yu, Qi, Commins, Caitlin, Bannon, Riley N., Corjuc, Bianca T., Chase, Alison, Diez, Lisa, Nguyen, Hoang-Oanh B., Hinkley, Sarah, Zhang, Lei, Goodwin, Alicia, Ledeboer, Annemarie, Lam, Stephen, Ankoudinova, Irina, Tran, Hung, Scarlott, Nicholas, Amora, Rainier, Surosky, Richard, Miller, Jeffrey C., Robbins, Ashley B., Rebar, Edward J., Urnov, Fyodor D., Holmes, Michael C., Pooler, Amy M., Riley, Brigit, Zhang, H. Steve, Hyman, Bradley T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978433/
https://ncbi.nlm.nih.gov/pubmed/33741591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe1611
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