Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signaling

Sepsis is the most common cause of death for patients in intensive care worldwide, due to a dysregulated host response to infection. Here, we investigate the role of sequestosome 1 (SQSTM1/p62), an autophagy receptor that functions as a regulator of innate immunity, in sepsis. We find that lipopolys...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Microbiol
Autors principals: Zhou, Borong, Liu, Jiao, Zeng, Ling, Zhu, Shan, Wang, Haichao, Billiar, Timothy R., Kroemer, Guido, Klionsky, Daniel J., Zeh, Herbert J., Jiang, Jianxin, Tang, Daolin, Kang, Rui
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7977680/
https://ncbi.nlm.nih.gov/pubmed/33077977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-00795-7
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars