Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signaling

Sepsis is the most common cause of death for patients in intensive care worldwide, due to a dysregulated host response to infection. Here, we investigate the role of sequestosome 1 (SQSTM1/p62), an autophagy receptor that functions as a regulator of innate immunity, in sepsis. We find that lipopolys...

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Veröffentlicht in:Nat Microbiol
Hauptverfasser: Zhou, Borong, Liu, Jiao, Zeng, Ling, Zhu, Shan, Wang, Haichao, Billiar, Timothy R., Kroemer, Guido, Klionsky, Daniel J., Zeh, Herbert J., Jiang, Jianxin, Tang, Daolin, Kang, Rui
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7977680/
https://ncbi.nlm.nih.gov/pubmed/33077977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-00795-7
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