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Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signaling
Sepsis is the most common cause of death for patients in intensive care worldwide, due to a dysregulated host response to infection. Here, we investigate the role of sequestosome 1 (SQSTM1/p62), an autophagy receptor that functions as a regulator of innate immunity, in sepsis. We find that lipopolys...
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| Publié dans: | Nat Microbiol |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7977680/ https://ncbi.nlm.nih.gov/pubmed/33077977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-00795-7 |
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