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SYNTHESIS AND ENANTIOSELECTIVITY OF CYCLOPROPAVIR PHOSPHATES FOR CELLULAR GMP KINASE
Enantiomeric cyclopropavir phosphates (+)-9 and (−)-9 were synthesized and investigated as substrates for GMP kinase. N(2)-Isobutyryl-di-O-acetylcyclopropavir (11) was converted to (+)-monoacetate 12 using hydrolysis catalyzed by porcine liver esterase. Phosphorylation via phosphite 13 gave after de...
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| Published in: | Nucleosides Nucleotides Nucleic Acids |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7976111/ https://ncbi.nlm.nih.gov/pubmed/20183619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770903172720 |
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