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Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase

Cyclopropavir (CPV) is a promising antiviral drug against human cytomegalovirus (HCMV). As with ganciclovir (GCV), the current standard for HCMV treatment, activation of CPV requires multiple steps of phosphorylation and is enantioselective. We hypothesized that the resulting CPV triphosphate (CPV-T...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Chen, Han, Li, Chengwei, Zemlicka, Jiri, Gentry, Brian G., Bowlin, Terry L., Coen, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914631/
https://ncbi.nlm.nih.gov/pubmed/27139481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00449-16
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