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Stereoselective Phosphorylation of Cyclopropavir by pUL97 and Competitive Inhibition by Maribavir

Human cytomegalovirus (HCMV) is a widespread pathogen that can cause severe disease in immunologically immature and immunocompromised individuals. Cyclopropavir (CPV) is a guanine nucleoside analog active against human and murine cytomegaloviruses in cell culture and efficacious in mice by oral admi...

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Bibliografiska uppgifter
Huvudupphovsmän: Gentry, Brian G., Kamil, Jeremy P., Coen, Donald M., Zemlicka, Jiri, Drach, John C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2010
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916337/
https://ncbi.nlm.nih.gov/pubmed/20547817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00468-10
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