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Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir
Synthesis of 6-deoxycyclopropavir (10), a prodrug of cyclopropavir (1) and its in vitro and in vivo antiviral activity is described. 2-Amino-6-chloropurine methylenecyclopropane 13 was transformed to its 6-iodo derivative 14 which was reduced to prodrug 10. It is converted to cyclopropavir (1) by th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690936/ https://ncbi.nlm.nih.gov/pubmed/22417649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.02.031 |
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