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Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir

Synthesis of 6-deoxycyclopropavir (10), a prodrug of cyclopropavir (1) and its in vitro and in vivo antiviral activity is described. 2-Amino-6-chloropurine methylenecyclopropane 13 was transformed to its 6-iodo derivative 14 which was reduced to prodrug 10. It is converted to cyclopropavir (1) by th...

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Main Authors: Li, Chengwei, Quenelle, Debra C., Prichard, Mark N., Drach, John C., Zemlicka, Jiri
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690936/
https://ncbi.nlm.nih.gov/pubmed/22417649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.02.031
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