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(Z)- and (E)-2-(1,2-Dihydroxyethyl)methylenecyclopropane Analogues of 2’-Deoxyadenosine and 2’-Deoxyguanosine. Synthesis of All Stereoisomers, Absolute Configuration and Antiviral Activity
Chiral Z and E-stereoisomers of (1,2-dihydroxyethyl)methylenecyclopropane analogues of 2’-deoxyadenosine and 2’-deoxyguanosine were synthesized and their antiviral activity investigated. (S)-Methylenecyclopropylcarbinol (16) was converted in seven steps to reagents 26 and 27 which were used for alky...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765047/ https://ncbi.nlm.nih.gov/pubmed/19397271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900126v |
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