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STEREOSELECTIVE APPROACH TO THE Z-ISOMERS OF METHYLENECYCLOPROPANE ANALOGUES OF NUCLEOSIDES: A NEW SYNTHESIS OF ANTIVIRAL SYNGUANOL

Stereoselective synthesis of antiviral synguanol (1) is described. Reaction of 6-benzyloxy-2-(dimethylaminomethyleneamino)purine (10) with ethyl (cis,trans)-2-chloro-2-(chloromethyl)cyclopropane-1-carboxylate (2c) under the conditions of alkylation-elimination gave (Z)-6-benzyloxy-2-formylamino-9-[(...

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Autors principals: Wu, Zhimeng, Zhou, Shaoman, Zemlicka, Jiri
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727591/
https://ncbi.nlm.nih.gov/pubmed/19333855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770902831060
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