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STEREOSELECTIVE APPROACH TO THE Z-ISOMERS OF METHYLENECYCLOPROPANE ANALOGUES OF NUCLEOSIDES: A NEW SYNTHESIS OF ANTIVIRAL SYNGUANOL
Stereoselective synthesis of antiviral synguanol (1) is described. Reaction of 6-benzyloxy-2-(dimethylaminomethyleneamino)purine (10) with ethyl (cis,trans)-2-chloro-2-(chloromethyl)cyclopropane-1-carboxylate (2c) under the conditions of alkylation-elimination gave (Z)-6-benzyloxy-2-formylamino-9-[(...
Bewaard in:
| Hoofdauteurs: | , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2727591/ https://ncbi.nlm.nih.gov/pubmed/19333855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770902831060 |
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