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Synthesis of Methylenecyclopropane Analogues of Antiviral Nucleoside Phosphonates

Synthesis of methylenecyclopropane analogues of nucleoside phosphonates 6a, 6b, 7a and 7b is described. Cyclopropyl phosphonate 8 was transformed in four steps to methylenecyclopropane phosphonate 16. The latter intermediate was converted in seven steps to the key Z- and E-methylenecyclopropane alco...

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Main Authors: Yan, Zhaohua, Zhou, Shaoman, Kern, Earl R., Zemlicka, Jiri
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474140/
https://ncbi.nlm.nih.gov/pubmed/16758001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2005.12.035
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