The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

Cells and organisms have a wide range of mechanisms to defend against infection by viruses and other mobile genetic elements (MGE). Type III CRISPR systems detect foreign RNA and typically generate cyclic oligoadenylate (cOA) second messengers that bind to ancillary proteins with CARF (CRISPR associ...

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Publicat a:Nucleic Acids Res
Autors principals: Zhu, Wenlong, McQuarrie, Stuart, Grüschow, Sabine, McMahon, Stephen A, Graham, Shirley, Gloster, Tracey M, White, Malcolm F
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2021
Matèries:
Nucleic Acid Enzymes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969007/
https://ncbi.nlm.nih.gov/pubmed/33590098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab073
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