The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

Cells and organisms have a wide range of mechanisms to defend against infection by viruses and other mobile genetic elements (MGE). Type III CRISPR systems detect foreign RNA and typically generate cyclic oligoadenylate (cOA) second messengers that bind to ancillary proteins with CARF (CRISPR associ...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Zhu, Wenlong, McQuarrie, Stuart, Grüschow, Sabine, McMahon, Stephen A, Graham, Shirley, Gloster, Tracey M, White, Malcolm F
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969007/
https://ncbi.nlm.nih.gov/pubmed/33590098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab073
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