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Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
The CRISPR system provides adaptive immunity against mobile genetic elements in prokaryotes. On binding invading RNA species, Type III CRISPR systems generate cyclic oligoadenylate (cOA) signalling molecules, potentiating a powerful immune response by activating downstream effector proteins, leading...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6981274/ https://ncbi.nlm.nih.gov/pubmed/31980625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14222-x |
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