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Ring nucleases deactivate Type III CRISPR ribonucleases by degrading cyclic oligoadenylate
The CRISPR system provides adaptive immunity against mobile genetic elements in prokaryotes, utilising small CRISPR RNAs which direct effector complexes to degrade invading nucleic acids1–3. Type III effector complexes were recently demonstrated to synthesise a novel second messenger, cyclic oligoad...
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| Publicado en: | Nature |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6219705/ https://ncbi.nlm.nih.gov/pubmed/30232454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0557-5 |
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