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A Type III CRISPR Ancillary Ribonuclease Degrades Its Cyclic Oligoadenylate Activator
Cyclic oligoadenylate (cOA) secondary messengers are generated by type III CRISPR systems in response to viral infection. cOA allosterically activates the CRISPR ancillary ribonucleases Csx1/Csm6, which degrade RNA non-specifically using a HEPN (Higher Eukaryotes and Prokaryotes, Nucleotide binding)...
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| Publicado no: | J Mol Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6599890/ https://ncbi.nlm.nih.gov/pubmed/31071326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.04.041 |
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