Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid of both invader and host. This can lead to dormancy...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Athukoralage, Januka S, McQuarrie, Stuart, Grüschow, Sabine, Graham, Shirley, Gloster, Tracey M, White, Malcolm F
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2020
Ämnen:
Biochemistry and Chemical Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371418/
https://ncbi.nlm.nih.gov/pubmed/32597755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57627
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk