Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors

N-Methyl-d-aspartate receptors (NMDARs) are ionotropic ligand-gated glutamate receptors that mediate fast excitatory synaptic transmission in the central nervous system (CNS). Several neurological disorders may involve NMDAR hypofunction, which has driven therapeutic interest in positive allosteric...

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Xehetasun bibliografikoak
Argitaratua izan da:ACS Chem Neurosci
Egile Nagusiak: Strong, Katie L., Epplin, Matthew P., Ogden, Kevin K., Burger, Pieter B., Kaiser, Thomas M., Wilding, Timothy J., Kusumoto, Hiro, Camp, Chad R., Shaulsky, Gil, Bhattacharya, Subhrajit, Perszyk, Riley E., Menaldino, David S., McDaniel, Miranda J., Zhang, Jing, Le, Phuong, Banke, Tue G., Hansen, Kasper B., Huettner, James E., Liotta, Dennis C., Traynelis, Stephen F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
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Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967294/
https://ncbi.nlm.nih.gov/pubmed/33326224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00561
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