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The Structure Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-D-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-D-Aspartate Receptors

We have identified a series of positive allosteric NMDA receptor (NMDAR) modulators derived from a known class of GluN2C/D-selective tetrahydroisoquinoline analogues that includes CIQ. The prototypical compound of this series contains a single isopropoxy moiety in place of the two methoxy substituen...

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Publicat a:J Med Chem
Autors principals: Strong, Katie L., Epplin, Matthew P., Bacsa, John, Butch, Christopher J., Burger, Pieter B., Menaldino, David S., Traynelis, Stephen F., Liotta, Dennis C.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916808/
https://ncbi.nlm.nih.gov/pubmed/28586221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00239
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