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Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-based Potentiators of GluN2C and GluN2D Containing N-Methyl-D-Aspartate Receptors

We describe here the synthesis and evaluation of a series of tetrahydroisoquinolines that show subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. Bischler-Napieralski conditions were employed in the key step for the conversion of acyclic amides to the correspo...

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Publicat a:J Med Chem
Autors principals: Santangelo Freel, Rose M., Ogden, Kevin K., Strong, Katie L., Khatri, Alpa, Chepiga, Kathryn M., Jensen, Henrik S., Traynelis, Stephen F., Liotta, Dennis C.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850841/
https://ncbi.nlm.nih.gov/pubmed/23627311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400177t
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