Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors

N-Methyl-d-aspartate receptors (NMDARs) are ionotropic ligand-gated glutamate receptors that mediate fast excitatory synaptic transmission in the central nervous system (CNS). Several neurological disorders may involve NMDAR hypofunction, which has driven therapeutic interest in positive allosteric...

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Bibliografiska uppgifter
I publikationen:ACS Chem Neurosci
Huvudupphovsmän: Strong, Katie L., Epplin, Matthew P., Ogden, Kevin K., Burger, Pieter B., Kaiser, Thomas M., Wilding, Timothy J., Kusumoto, Hiro, Camp, Chad R., Shaulsky, Gil, Bhattacharya, Subhrajit, Perszyk, Riley E., Menaldino, David S., McDaniel, Miranda J., Zhang, Jing, Le, Phuong, Banke, Tue G., Hansen, Kasper B., Huettner, James E., Liotta, Dennis C., Traynelis, Stephen F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967294/
https://ncbi.nlm.nih.gov/pubmed/33326224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00561
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