Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors

N-Methyl-d-aspartate receptors (NMDARs) are ionotropic ligand-gated glutamate receptors that mediate fast excitatory synaptic transmission in the central nervous system (CNS). Several neurological disorders may involve NMDAR hypofunction, which has driven therapeutic interest in positive allosteric...

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Publicat a:ACS Chem Neurosci
Autors principals: Strong, Katie L., Epplin, Matthew P., Ogden, Kevin K., Burger, Pieter B., Kaiser, Thomas M., Wilding, Timothy J., Kusumoto, Hiro, Camp, Chad R., Shaulsky, Gil, Bhattacharya, Subhrajit, Perszyk, Riley E., Menaldino, David S., McDaniel, Miranda J., Zhang, Jing, Le, Phuong, Banke, Tue G., Hansen, Kasper B., Huettner, James E., Liotta, Dennis C., Traynelis, Stephen F.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7967294/
https://ncbi.nlm.nih.gov/pubmed/33326224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00561
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