The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor

N-methyl-d-aspartate (NMDA) receptors are ligand-gated, cation-selective channels that mediate a slow component of excitatory synaptic transmission. Subunit-selective positive allosteric modulators of NMDA receptor function have therapeutically relevant effects on multiple processes in the brain. A...

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Publicado no:Mol Pharmacol
Main Authors: Kaiser, Thomas M., Kell, Steven A., Kusumoto, Hirofumi, Shaulsky, Gil, Bhattacharya, Subhrajit, Epplin, Matthew P., Strong, Katie L., Miller, Eric J., Cox, Bryan D., Menaldino, David S., Liotta, Dennis C., Traynelis, Stephen F., Burger, Pieter B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767683/
https://ncbi.nlm.nih.gov/pubmed/29242355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110940
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