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The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor

N-methyl-d-aspartate (NMDA) receptors are ligand-gated, cation-selective channels that mediate a slow component of excitatory synaptic transmission. Subunit-selective positive allosteric modulators of NMDA receptor function have therapeutically relevant effects on multiple processes in the brain. A...

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書誌詳細
出版年:Mol Pharmacol
主要な著者: Kaiser, Thomas M., Kell, Steven A., Kusumoto, Hirofumi, Shaulsky, Gil, Bhattacharya, Subhrajit, Epplin, Matthew P., Strong, Katie L., Miller, Eric J., Cox, Bryan D., Menaldino, David S., Liotta, Dennis C., Traynelis, Stephen F., Burger, Pieter B.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767683/
https://ncbi.nlm.nih.gov/pubmed/29242355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110940
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