Structural Determinants and Mechanism of Action of a GluN2C-selective NMDA Receptor Positive Allosteric Modulator

NMDA receptors are tetrameric complexes of GluN1, GluN2A-D, and GluN3A-B subunits and are involved in normal brain function and neurologic disorders. We identified a novel class of stereoselective pyrrolidinone (PYD) positive allosteric modulators for GluN2C-containing NMDA receptors, exemplified by...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Khatri, Alpa, Burger, Pieter B., Swanger, Sharon A., Hansen, Kasper B., Zimmerman, Sommer, Karakas, Erkan, Liotta, Dennis C., Furukawa, Hiro, Snyder, James P., Traynelis, Stephen F.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2014
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201136/
https://ncbi.nlm.nih.gov/pubmed/25205677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.094516
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars