Structural Determinants and Mechanism of Action of a GluN2C-selective NMDA Receptor Positive Allosteric Modulator

NMDA receptors are tetrameric complexes of GluN1, GluN2A-D, and GluN3A-B subunits and are involved in normal brain function and neurologic disorders. We identified a novel class of stereoselective pyrrolidinone (PYD) positive allosteric modulators for GluN2C-containing NMDA receptors, exemplified by...

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Main Authors: Khatri, Alpa, Burger, Pieter B., Swanger, Sharon A., Hansen, Kasper B., Zimmerman, Sommer, Karakas, Erkan, Liotta, Dennis C., Furukawa, Hiro, Snyder, James P., Traynelis, Stephen F.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201136/
https://ncbi.nlm.nih.gov/pubmed/25205677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.094516
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