The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor

N-methyl-d-aspartate (NMDA) receptors are ligand-gated, cation-selective channels that mediate a slow component of excitatory synaptic transmission. Subunit-selective positive allosteric modulators of NMDA receptor function have therapeutically relevant effects on multiple processes in the brain. A...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Kaiser, Thomas M., Kell, Steven A., Kusumoto, Hirofumi, Shaulsky, Gil, Bhattacharya, Subhrajit, Epplin, Matthew P., Strong, Katie L., Miller, Eric J., Cox, Bryan D., Menaldino, David S., Liotta, Dennis C., Traynelis, Stephen F., Burger, Pieter B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767683/
https://ncbi.nlm.nih.gov/pubmed/29242355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110940
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