Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair

Recent studies have implicated DNA polymerases θ (Pol θ) and β (Pol β) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal translocations. Here we identify subunits of the replicative DNA polymerase δ (Pol δ) as promoters of Alt-NHEJ that results in more ex...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Layer, Jacob V., Debaize, Lydie, Van Scoyk, Alexandria, House, Nealia C., Brown, Alexander J., Liu, Yunpeng, Stevenson, Kristen E., Hemann, Michael, Roberts, Steven A., Price, Brendan D., Weinstock, David M., Day, Tovah A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959522/
https://ncbi.nlm.nih.gov/pubmed/33077594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014176117
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge