Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair

Recent studies have implicated DNA polymerases θ (Pol θ) and β (Pol β) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal translocations. Here we identify subunits of the replicative DNA polymerase δ (Pol δ) as promoters of Alt-NHEJ that results in more ex...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Layer, Jacob V., Debaize, Lydie, Van Scoyk, Alexandria, House, Nealia C., Brown, Alexander J., Liu, Yunpeng, Stevenson, Kristen E., Hemann, Michael, Roberts, Steven A., Price, Brendan D., Weinstock, David M., Day, Tovah A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959522/
https://ncbi.nlm.nih.gov/pubmed/33077594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014176117
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