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A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair
Recurrent reciprocal translocations are present in many hematologic and mesenchymal malignancies. Because significant sequence homology is absent from translocation breakpoint junctions, non-homologous end-joining (NHEJ) pathways of DNA repair are presumed to catalyze their formation. We developed t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society of Hematology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895622/ https://ncbi.nlm.nih.gov/pubmed/16195334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2437 |
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