A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair

Recurrent reciprocal translocations are present in many hematologic and mesenchymal malignancies. Because significant sequence homology is absent from translocation breakpoint junctions, non-homologous end-joining (NHEJ) pathways of DNA repair are presumed to catalyze their formation. We developed t...

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Detaylı Bibliyografya
Asıl Yazarlar: Weinstock, David M., Elliott, Beth, Jasin, Maria
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society of Hematology 2006
Konular:
Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895622/
https://ncbi.nlm.nih.gov/pubmed/16195334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2437
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