Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair

Recent studies have implicated DNA polymerases θ (Pol θ) and β (Pol β) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal translocations. Here we identify subunits of the replicative DNA polymerase δ (Pol δ) as promoters of Alt-NHEJ that results in more ex...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Layer, Jacob V., Debaize, Lydie, Van Scoyk, Alexandria, House, Nealia C., Brown, Alexander J., Liu, Yunpeng, Stevenson, Kristen E., Hemann, Michael, Roberts, Steven A., Price, Brendan D., Weinstock, David M., Day, Tovah A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959522/
https://ncbi.nlm.nih.gov/pubmed/33077594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014176117
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