Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair

Recent studies have implicated DNA polymerases θ (Pol θ) and β (Pol β) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal translocations. Here we identify subunits of the replicative DNA polymerase δ (Pol δ) as promoters of Alt-NHEJ that results in more ex...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Layer, Jacob V., Debaize, Lydie, Van Scoyk, Alexandria, House, Nealia C., Brown, Alexander J., Liu, Yunpeng, Stevenson, Kristen E., Hemann, Michael, Roberts, Steven A., Price, Brendan D., Weinstock, David M., Day, Tovah A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959522/
https://ncbi.nlm.nih.gov/pubmed/33077594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014176117
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