Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair

Recent studies have implicated DNA polymerases θ (Pol θ) and β (Pol β) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal translocations. Here we identify subunits of the replicative DNA polymerase δ (Pol δ) as promoters of Alt-NHEJ that results in more ex...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Layer, Jacob V., Debaize, Lydie, Van Scoyk, Alexandria, House, Nealia C., Brown, Alexander J., Liu, Yunpeng, Stevenson, Kristen E., Hemann, Michael, Roberts, Steven A., Price, Brendan D., Weinstock, David M., Day, Tovah A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959522/
https://ncbi.nlm.nih.gov/pubmed/33077594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014176117
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