PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

Chromosomal rearrangements are essential events in the pathogenesis of both malignant and nonmalignant disorders, yet the factors affecting their formation are incompletely understood. Here we develop a zinc-finger nuclease translocation reporter and screen for factors that modulate rearrangements i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Day, Tovah A., Layer, Jacob V., Cleary, J. Patrick, Guha, Srijoy, Stevenson, Kristen E., Tivey, Trevor, Kim, Sunhee, Schinzel, Anna C., Izzo, Francesca, Doench, John, Root, David E., Hahn, William C., Price, Brendan D., Weinstock, David M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414184/
https://ncbi.nlm.nih.gov/pubmed/28447610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15110
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