PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

Chromosomal rearrangements are essential events in the pathogenesis of both malignant and nonmalignant disorders, yet the factors affecting their formation are incompletely understood. Here we develop a zinc-finger nuclease translocation reporter and screen for factors that modulate rearrangements i...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Day, Tovah A., Layer, Jacob V., Cleary, J. Patrick, Guha, Srijoy, Stevenson, Kristen E., Tivey, Trevor, Kim, Sunhee, Schinzel, Anna C., Izzo, Francesca, Doench, John, Root, David E., Hahn, William C., Price, Brendan D., Weinstock, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414184/
https://ncbi.nlm.nih.gov/pubmed/28447610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15110
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