MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria

Mutations in mitochondrial replicative polymerase PolγA lead to progressive external ophthalmoplegia (PEO). While PolγA is the known central player in mitochondrial DNA (mtDNA) replication, it is unknown whether a regulatory process exists on the mitochondrial outer membrane which controlled its ent...

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Publicat a:PLoS Biol
Autors principals: Hussain, Mansoor, Mohammed, Aftab, Saifi, Shabnam, Khan, Aamir, Kaur, Ekjot, Priya, Swati, Agarwal, Himanshi, Sengupta, Sagar
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959396/
https://ncbi.nlm.nih.gov/pubmed/33657094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001139
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