MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria

Mutations in mitochondrial replicative polymerase PolγA lead to progressive external ophthalmoplegia (PEO). While PolγA is the known central player in mitochondrial DNA (mtDNA) replication, it is unknown whether a regulatory process exists on the mitochondrial outer membrane which controlled its ent...

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Detaylı Bibliyografya
Yayımlandı:PLoS Biol
Asıl Yazarlar: Hussain, Mansoor, Mohammed, Aftab, Saifi, Shabnam, Khan, Aamir, Kaur, Ekjot, Priya, Swati, Agarwal, Himanshi, Sengupta, Sagar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959396/
https://ncbi.nlm.nih.gov/pubmed/33657094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001139
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