MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

Mutations in BLM in Bloom Syndrome patients predispose them to multiple types of cancers. Here we report that BLM is recruited in a biphasic manner to annotated DSBs. BLM recruitment is dependent on the presence of NBS1, MRE11 and ATM. While ATM activity is essential for BLM recruitment in early pha...

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Pubblicato in:Nat Commun
Autori principali: Tripathi, Vivek, Agarwal, Himanshi, Priya, Swati, Batra, Harish, Modi, Priyanka, Pandey, Monica, Saha, Dhurjhoti, Raghavan, Sathees C., Sengupta, Sagar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844875/
https://ncbi.nlm.nih.gov/pubmed/29523790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03393-8
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