MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways

Mutations in BLM in Bloom Syndrome patients predispose them to multiple types of cancers. Here we report that BLM is recruited in a biphasic manner to annotated DSBs. BLM recruitment is dependent on the presence of NBS1, MRE11 and ATM. While ATM activity is essential for BLM recruitment in early pha...

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Vydáno v:Nat Commun
Hlavní autoři: Tripathi, Vivek, Agarwal, Himanshi, Priya, Swati, Batra, Harish, Modi, Priyanka, Pandey, Monica, Saha, Dhurjhoti, Raghavan, Sathees C., Sengupta, Sagar
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844875/
https://ncbi.nlm.nih.gov/pubmed/29523790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03393-8
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