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Chk1-dependent constitutive phosphorylation of BLM helicase at Serine 646 decreases after DNA damage
BLM helicase, the protein mutated in Bloom Syndrome, is involved in signal transduction cascades after DNA damage. BLM is phosphorylated on multiple residues by different kinases either after stress induction or during mitosis. Here we have provided evidence that both Chk1 and Chk2 phosphorylated th...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2941563/ https://ncbi.nlm.nih.gov/pubmed/20719863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-10-0233 |
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