Ubiquitin-dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination

Limiting the levels of homologous recombination (HR) that occur at sites of DNA damage is a major role of BLM helicase. However, very little is known about the mechanisms dictating its relocalization to these sites. Here, we demonstrate that the ubiquitin/SUMO-dependent DNA damage response (UbS-DDR)...

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Autori principali: Tikoo, Shweta, Madhavan, Vinoth, Hussain, Mansoor, Miller, Edward S, Arora, Prateek, Zlatanou, Anastasia, Modi, Priyanka, Townsend, Kelly, Stewart, Grant S, Sengupta, Sagar
Natura: Artigo
Lingua:Inglês
Pubblicazione: European Molecular Biology Organization 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680739/
https://ncbi.nlm.nih.gov/pubmed/23708797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.117
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