Ubiquitin-dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination

Limiting the levels of homologous recombination (HR) that occur at sites of DNA damage is a major role of BLM helicase. However, very little is known about the mechanisms dictating its relocalization to these sites. Here, we demonstrate that the ubiquitin/SUMO-dependent DNA damage response (UbS-DDR)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tikoo, Shweta, Madhavan, Vinoth, Hussain, Mansoor, Miller, Edward S, Arora, Prateek, Zlatanou, Anastasia, Modi, Priyanka, Townsend, Kelly, Stewart, Grant S, Sengupta, Sagar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: European Molecular Biology Organization 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680739/
https://ncbi.nlm.nih.gov/pubmed/23708797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.117
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