MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites

Unresolved endoplasmic reticulum (ER) stress shifts the unfolded protein response signaling from cell survival to cell death, although the switching mechanism remains unclear. Here, we report that mitochondrial ubiquitin ligase (MITOL/MARCH5) inhibits ER stress‐induced apoptosis through ubiquitylati...

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Bibliografiset tiedot
Julkaisussa:EMBO J
Päätekijät: Takeda, Keisuke, Nagashima, Shun, Shiiba, Isshin, Uda, Aoi, Tokuyama, Takeshi, Ito, Naoki, Fukuda, Toshifumi, Matsushita, Nobuko, Ishido, Satoshi, Iwawaki, Takao, Uehara, Takashi, Inatome, Ryoko, Yanagi, Shigeru
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2019
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669929/
https://ncbi.nlm.nih.gov/pubmed/31368599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100999
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