MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress

Mitochondrial abnormalities are associated with developmental disorders, although a causal relationship remains largely unknown. Here, we report that increased oxidative stress in neurons by deletion of mitochondrial ubiquitin ligase MITOL causes a potential neuroinflammation including aberrant astr...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Nagashima, Shun, Takeda, Keisuke, Ohno, Nobuhiko, Ishido, Satoshi, Aoki, Motohide, Saitoh, Yurika, Takada, Takumi, Tokuyama, Takeshi, Sugiura, Ayumu, Fukuda, Toshifumi, Matsushita, Nobuko, Inatome, Ryoko, Yanagi, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696985/
https://ncbi.nlm.nih.gov/pubmed/31416892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900308
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