MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites

Unresolved endoplasmic reticulum (ER) stress shifts the unfolded protein response signaling from cell survival to cell death, although the switching mechanism remains unclear. Here, we report that mitochondrial ubiquitin ligase (MITOL/MARCH5) inhibits ER stress‐induced apoptosis through ubiquitylati...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Takeda, Keisuke, Nagashima, Shun, Shiiba, Isshin, Uda, Aoi, Tokuyama, Takeshi, Ito, Naoki, Fukuda, Toshifumi, Matsushita, Nobuko, Ishido, Satoshi, Iwawaki, Takao, Uehara, Takashi, Inatome, Ryoko, Yanagi, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669929/
https://ncbi.nlm.nih.gov/pubmed/31368599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100999
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