Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation

Kinases play important roles in diverse cellular processes, including signaling, differentiation, proliferation, and metabolism. They are frequently mutated in cancer and are the targets of a large number of specific inhibitors. Surveys of cancer genome atlases reveal that kinase domains, which cons...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Proc Natl Acad Sci U S A
Κύριοι συγγραφείς: Patil, Keshav, Jordan, Earl Joseph, Park, Jin H., Suresh, Krishna, Smith, Courtney M., Lemmon, Abigail A., Mossé, Yaël P., Lemmon, Mark A., Radhakrishnan, Ravi
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2021
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958353/
https://ncbi.nlm.nih.gov/pubmed/33674381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019132118
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