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Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation
Kinases play important roles in diverse cellular processes, including signaling, differentiation, proliferation, and metabolism. They are frequently mutated in cancer and are the targets of a large number of specific inhibitors. Surveys of cancer genome atlases reveal that kinase domains, which cons...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7958353/ https://ncbi.nlm.nih.gov/pubmed/33674381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019132118 |
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