Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation

Kinases play important roles in diverse cellular processes, including signaling, differentiation, proliferation, and metabolism. They are frequently mutated in cancer and are the targets of a large number of specific inhibitors. Surveys of cancer genome atlases reveal that kinase domains, which cons...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Patil, Keshav, Jordan, Earl Joseph, Park, Jin H., Suresh, Krishna, Smith, Courtney M., Lemmon, Abigail A., Mossé, Yaël P., Lemmon, Mark A., Radhakrishnan, Ravi
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958353/
https://ncbi.nlm.nih.gov/pubmed/33674381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019132118
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